Adipokine regulation and antitumor effect by apple procyanidins
Adipokine regulation and antitumor effect by apple procyanidins
批准号:
20580121
负责人:
KASAI Kosuke
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In this study, anti-tumor action of the apple procyanidins (ACT) in obesity mouse model, in which high-fat diet (HFD) was fed with C57BL/6J mouse, was investigated. The expression of adipokine, cytokine and apoptosis-related genes in adipose, spleen and tumor tissue were analyzed by real-time RT-PCR after transplantation with B16 melanoma cells. Obesity mice fed with ACT (HFD-ACT) showed 65.4 % of tumor volume decrease. It is indicated that the ACT suppressed the obesity-related acceleration of tumor growth by activation of the anti-tumor immunity and suppression of growth signal in tumor cells.
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DOI:
10.1111/j.1742-4658.2009.07497.x
发表时间:
2010-01-01
期刊:
FEBS JOURNAL
影响因子:
5.4
作者:
[Kasai, Kosuke, Ishikawa, Takashi, Miura, Tomisato]
通讯作者:
Miura, Tomisato
ホームページ等。
主页等
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影响因子:
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作者:
[]
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苹果原花青素诱导DR5表达及其与TRAIL的联合作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
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[三浦富智]
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三浦富智
Invadopodia formation by bladder tumor cells.
膀胱肿瘤细胞形成侵袭伪足。
DOI:
--
发表时间:
2010
期刊:
Oncol Res 19
影响因子:
--
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[Sutoh M, Hashimoto Y, Koie T, et al.]
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et al.
Localization of sense and antisense transcripts of Prdx 2 eene in mouse tissues
Prdx 2 eene 有义和反义转录本在小鼠组织中的定位
DOI:
--
发表时间:
2008
期刊:
Cytogenet Genome Res 121
影响因子:
--
作者:
[石森, et al., Chiba M]
通讯作者:
Chiba M
共 10 条
A Comparative Study on Parental Participation Systems in School Administration: Exploring the Global Standard
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批准号:16K17388
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2016
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负责人:KASAI Kosuke
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依托单位:
海外基金