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Adipokine regulation and antitumor effect by apple procyanidins

Adipokine regulation and antitumor effect by apple procyanidins
苹果原花青素的脂肪因子调节和抗肿瘤作用
批准号:
20580121
负责人:
KASAI Kosuke
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In this study, anti-tumor action of the apple procyanidins (ACT) in obesity mouse model, in which high-fat diet (HFD) was fed with C57BL/6J mouse, was investigated. The expression of adipokine, cytokine and apoptosis-related genes in adipose, spleen and tumor tissue were analyzed by real-time RT-PCR after transplantation with B16 melanoma cells. Obesity mice fed with ACT (HFD-ACT) showed 65.4 % of tumor volume decrease. It is indicated that the ACT suppressed the obesity-related acceleration of tumor growth by activation of the anti-tumor immunity and suppression of growth signal in tumor cells.
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DOI: 10.1111/j.1742-4658.2009.07497.x
发表时间: 2010-01-01
期刊: FEBS JOURNAL
影响因子: 5.4
作者: [Kasai, Kosuke, Ishikawa, Takashi, Miura, Tomisato]
通讯作者: Miura, Tomisato
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
リンゴプロシアニジンによるDR5発現誘導とTRAILとの併用効果
苹果原花青素诱导DR5表达及其与TRAIL的联合作用
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [三浦富智]
通讯作者: 三浦富智
Invadopodia formation by bladder tumor cells.
膀胱肿瘤细胞形成侵袭伪足。
DOI: --
发表时间: 2010
期刊: Oncol Res 19
影响因子: --
作者: [Sutoh M, Hashimoto Y, Koie T, et al.]
通讯作者: et al.
10
    A Comparative Study on Parental Participation Systems in School Administration: Exploring the Global Standard
    • 批准号:
      16K17388
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.25万
    • 财政年份:
      2016
    • 负责人:
      KASAI Kosuke
    • 依托单位:
    海外基金