Molecular modeling of food-grade compounds with anti-conformational disease effects by using amyloidogenic proteins

利用分别与遗传性胱抑素C淀粉样血管病和阿尔茨海默病相关的含有半胱氨酸氨基转移酶C L68Q变异体和Aβ的淀粉样蛋白，研究了天然酚类化合物及其糖基和脂类衍生物的抗构象疾病作用。结果表明，冷冻干燥比糖基化更能有效地提高受试酚类化合物的抗淀粉样变性。这些关于构象-功能关系的观察结果可能有助于设计新的抑制剂作为淀粉样蛋白相关疾病的治疗剂。

Anti-conformational disease effects of naturally-occurring phenolic compounds and their glycosyl and lipophilic derivatives were investigated by using amyloidogenic proteins containing cystatin C L68Q variant and A β which are responsible for hereditary cystatin C amyloid angiopathy and Alzheimer's disease, respectively. As the result, it was revealed that lyophilization was more effective than glycosylation for improving anti-amyloidgenicity of the tested phenolic compounds. These observations regarding conformation-functional relationship can be useful for novel inhibitors' design as therapeutic agents for amyloid-associated diseases.