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Development of the safe and functional avirulent neurotracing virus producing system.

Development of the safe and functional avirulent neurotracing virus producing system.
开发安全且功能性的无毒神经追踪病毒生产系统。
批准号:
20580319
负责人:
TANIGUCHI Takahide
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The entire genome sequence of the porcine hamagglutinating encephalomyelitis virus (PHEV) 67N strain, neurotropic coronavirus, was determined, and the sequence data is useful for reverse genetics of PHEV to develop the PHEV based neurotracing virus. There is about 400 base insertion in ns2 gene of neurotropic 67N strain and 200 base deletion in ns2 gene of non neurotropic OSN204 strain. The results of in vitro PHEV infection to Neuroblastoma and glioma cell line indicated that PHEV 67N strain have high neurotropism.
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通讯作者:
Study of the extensively usable coronaviruses infrction model-mouse production.
Analysis of immunopahtological mechanisms induced by virus infected macrophages.
  • 批准号:
    14560246
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.18万
  • 财政年份:
    2002
  • 负责人:
    TANIGUCHI Takahide
  • 依托单位:
Functional analysis of Tumor necrosis Factor α(TNFα) on infections immunity.
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