Role of the TGF-β family and Mitf during osteoclastogenesis

我们探讨了调节广泛生物学过程的TGF-β家族和组织特异性转录因子Mitf在RANKL诱导破骨细胞形成过程中的作用。本研究表明，Mitf-E在破骨细胞发生中起着至关重要的作用，并且TGF-β家族正调控Mitf-E以及破骨细胞标志物基因的表达。TGF-β家族对破骨细胞生成的刺激活性可能部分通过上调Mitf-E而引起。

We explored the role of TGF-β family that regulates a broad range of biological processes and Mitf that is a tissue-specific transcription factor, in the process of RANKL-induced osteoclast formation. This study indicates that Mitf-E plays a crucial role in osteoclastogenesis, and that the TGF-β family positively regulates the expression of Mitf-E as well as osteoclast marker genes. Stimulatory activity of the TGF-β family on osteoclastogenesis may be partly elicited through up-regulation of Mitf-E.