Synthetic Studies toward Kinamycin-Jadomycin Antibiotics

以溴化萘为AB环，苯基硼酸为D环，通过“萘路线”合成了前激动素和杰多霉素A。通过AB-D环单元的C环形成，再经过重氮化反应合成了前一种化合物。后者是通过引入异亮氨酸和脱保护合成的。通过在同一种合成中间体的D环上引入氧官能团，得到了激动素的基本碳骨架。

Total syntheses of prekinamycin and jadomycin A were achieved via "naphthalene route", Suzuki-Miyaura coupling of bromonaphthalene unit as AB ring and phenylboronic acid as D ring part. C ring formation of AB-D ring unit followed by diazotization lead to the synthesis of the former compound. The latter was synthesized by introduction of isoleucine and deprotection. The basic carbon skeleton of kinamycins was also achieved by introduction of oxygen functionality on D ring of same synthetic intermediate of prekinamycin.