セレン蛋白質GPx4による新規細胞増殖制御機構の解析

磷脂氢谷胱甘肽过氧化物酶(Gpx4)是一种重要的抗氧化酶，能直接还原氧化应激下生物膜中产生的磷脂氢过氧化物。破坏Gpx4可诱导多种组织和MEF细胞的细胞死亡。多项实验证明，这种由Gpx4缺失引起的细胞死亡不是一种典型的细胞死亡，如凋亡、坏死和自噬细胞死亡，而是一种新的细胞死亡。

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is one of the most important antioxidant enzymes that directly reduce phospholipid hydroperoxide generated in biomembrane by oxidative stress. Disruption of GPx4 induce cell death in in several tissues and MEF cells. Several experiments demonstrated that this cell death induced by depletion of GPx4 is not a canonical cell death, such as apoptosis, necrosis and autophagic cell death, but a novel cell death.