セレン蛋白質GPx4による新規細胞増殖制御機構の解析

磷脂氢过氧化物谷胱甘肽过氧化物酶（GPx4）是直接还原生物膜氧化应激产生的磷脂氢过氧化物的最重要的抗氧化酶之一。GPx4的破坏可导致多种组织和MEF细胞的细胞死亡。多项实验表明，GPx4缺失诱导的细胞死亡不是典型的细胞死亡，如凋亡、坏死和自噬细胞死亡，而是一种新型的细胞死亡。

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is one of the most important antioxidant enzymes that directly reduce phospholipid hydroperoxide generated in biomembrane by oxidative stress. Disruption of GPx4 induce cell death in in several tissues and MEF cells. Several experiments demonstrated that this cell death induced by depletion of GPx4 is not a canonical cell death, such as apoptosis, necrosis and autophagic cell death, but a novel cell death.