Study on TRP ion channels activation by carbonyl compounds in indoor environments

为了阐明室内环境引起的健康问题的机制，我们建立了稳定表达6种瞬时受体电位（TRP）离子通道的转化子，并建立了高通量筛选激活TRP离子通道的室内化学物质的方法。在这项研究中，我们证明了柠檬烯氧化产物、1-甲基-4-乙酰基环己烯等室内羰基化合物会激活人TRPA 1，已知该通道是气道化学感觉和炎症中的感觉神经元TRP离子通道。

In order to clarify the mechanism of health problems caused by indoor environments, we established transformants stably expressing the 6 transient receptor potential (TRP) channels, and developed a high throughput assay for the screening the indoor chemicals which activates the TRP ion channels. In this study, we demonstrated that indoor carbonyl compounds such as a limonene oxidation product, 1-methyl-4-acetylcyclohexene activated human TRPA1, which is known to be a sensory neuronal TRP ion channel in airway chemosensation and inflammation.