Study on evaluation system for drug cardiotoxicity using on-chip cell-besed analysis and quality examination of generic products of injection

我们利用培养细胞和实验动物考察了注射用仿制产品的药品质量和安全性，并研究了基于芯片心肌细胞网络细胞分析的药物心脏毒性评价方法的发展。因此，监测药物治疗后对网络细胞搏动节律的影响可以估计离子通道条件，这表明它可能是一种基于细胞的药物心脏毒性测量系统。本研究检测的仿制注射剂的药品质量和安全性与创新注射剂相当。

We investigated the pharmaceutical quality and safety of generic products of injection using a cultured cell and an experimental animal, and examined the development of the method to evaluate drug cardiotoxicity by an on-chip cardiomyocyte network cell-based analysis. As a result, monitoring of effects on the beating rhythms of the network cells after treatment of agents could us estimate the ionic channel conditions, suggesting that it might be useful as a cell-based measurement system for drug cardiotoxicity. The pharmaceutical quality and safety of generic injections tested in this study were comparable to the innovator injections.