Neural regulatory mechanisms of cardiopulmonary function in hypoxic conditions.

本研究利用大鼠急性和慢性低氧性肺动脉高压、急性出血性低血压、睡眠呼吸暂停综合征和急性心肌梗死模型以及M2胆碱能受体基因敲除小鼠，阐明了交感神经系统介导的肺血管张力、心率和节律的调控是低氧、运动或心肌缺血条件下生存所必需的。此外，本研究还提示Ghrelin通过调节植物神经功能，对心肌梗死和肺动脉高压具有心肺保护作用。

Using rat models of acute and chronic hypoxic pulmonary hypertension, acute hemorrhagic hypotension, sleep apnea syndrome and acute myocardial infarction, and M2 muscarinic cholinergic receptor KO mice, this study clarified that the sympathetic nervous system-mediated control of pulmonary vascular tone and heart rate and rhythm is essential to survive under the condition of hypoxia, exercise or cardiac ischemia. Furthermore, this study suggested that ghrelin, which regulates the autonomic nerve function, has cardiopulmonary protective effects in myocardial infarction and pulmonary hypertension.