Neural regulatory mechanisms of cardiopulmonary function in hypoxic conditions.

缺氧条件下心肺功能的神经调节机制。

• 批准号: 20590242
• 负责人: SHIRAI Mikiyasu
• 金额: $ 2.5万
• 依托单位: Hiroshima International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590242/
• 关键词: 低酸素; 肺高血圧; 出血性低血圧; 睡眠時無呼吸症候群; 心筋梗塞; グレリン; ムスカリン性アセチルコリン受容体; 交感神経; βアドレナリン受容体; Rho-kinase; 心臓交感神経; 不整脈; 低酸素性肺高血圧; 放射光; マウス肺血管造影; 肺交感神経; 低酸素性肺血管収縮; β-アドレナリン受容体; 副腎

Using rat models of acute and chronic hypoxic pulmonary hypertension, acute hemorrhagic hypotension, sleep apnea syndrome and acute myocardial infarction, and M2 muscarinic cholinergic receptor KO mice, this study clarified that the sympathetic nervous system-mediated control of pulmonary vascular tone and heart rate and rhythm is essential to survive under the condition of hypoxia, exercise or cardiac ischemia. Furthermore, this study suggested that ghrelin, which regulates the autonomic nerve function, has cardiopulmonary protective effects in myocardial infarction and pulmonary hypertension.

本研究通过急性和慢性缺氧性肺动脉高压、急性出血性低血压、睡眠呼吸暂停综合征和急性心肌梗死大鼠模型以及M2毒蕈碱胆碱能受体KO小鼠模型，阐明了交感神经系统介导的肺血管张力和心率节律的控制是在缺氧、运动或心脏缺血条件下生存所必需的。此外，本研究提示调节自主神经功能的胃饥饿素在心肌梗死和肺动脉高压中具有心肺保护作用。

项目成果

Dynamic synchrotron imaging of the coronary vasculature in vivo in rat models of heart failure and diabetes.

心力衰竭和糖尿病大鼠模型体内冠状脉管系统的动态同步加速器成像。

• 发表时间: 2009
• 作者: Pearson J;Jenkins MJ;Okura Y;Tani D;Schwenke DO;Umetani K;Kangawa K;Shirai M
• 通讯作者: Shirai M

Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiography

• DOI: 10.1152/japplphysiol.00610.2007
• 发表时间: 2008-01-01
• 期刊: JOURNAL OF APPLIED PHYSIOLOGY
• 影响因子: 3.3
• 作者: Schwenke, Daryl O.;Pearson, James T.;Shirai, Mikiyasu
• 通讯作者: Shirai, Mikiyasu

Contrast angiography of the rat renal microcirculation in vivo using synchrotron radiation

• DOI: 10.1152/ajprenal.90499.2008
• 发表时间: 2009-05-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
• 影响因子: 4.2
• 作者: Eppel, Gabriela A.;Lo Jacono, David;Pearson, James T.
• 通讯作者: Pearson, James T.

Imaging on the closed-chest mouse pulmonary circulation using synchrotron radiation micro- angiography.

使用同步辐射显微血管造影对闭胸小鼠肺循环进行成像。

• 发表时间: 2011
• 期刊: J.Appl.Physiol. Epub ahead of print
• 作者: Sonobe T;Schwenke DO;Pearson JT;Yoshimoto M;Fujii Y;Umetani K;Shirai M
• 通讯作者: Shirai M

Role of Ca^<2+>-activated K^+ channels in catecholamine release from in vivo rat adrenal medulla.

Ca 2+ 激活的K 2 通道在儿茶酚胺从体内大鼠肾上腺髓质释放中的作用。

• 发表时间: 2010
• 期刊: Neurochem Int
• 影响因子: 4.2
• 作者: Akiyama;T.
• 通讯作者: T.