Investigation for application of Terahertz-Wave spectroscopy to high-accurated histopathological analysis

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By using Terahertz-Wave spectroscopy which has the following characteristics : 1) going straight and transmittance, 2) easy to obtain the wave for imaging, 3) having molecular-specific "fingerprint wave", and 4) non invasive to human body, different from X-ray, we performed the high-accurated histopathological analysis. Results we obtained were follows ;1) Terahertz-wave spectroscopy for precise histopathological image analysis using paraffin-embedded sections.Miura Y, et al : Tohoku J Exp Med. 223 : 291-6(2011)2) Terahertz-wave spectroscopy applicable for intraoperative quick diagnosis using fresh frozen specimen ( in preparation)3) In analyze the histological factors which influence the transmittance of Terahertz-Wave, it was demonstrated that the factors related on transmittance of Terahertz-Wave depend on not only the density of cell/tissue, but also the conditions such as inflammation, nectrosis and fibrosis and so on.4) Application of Terahertz-wave spectroscopy for Immunohistochemical staining which is able to be analyze both the chemical component as well as histopathological features.From our results for three years, the terahertz-wave spectroscopy would be a useful tool for high-accurated histopathological and chemical analyses.