Mechanism underlying functional impairment of hematopoietic stem cell niches caused by oxidative stress at the site of xenobiotic interrelationship

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The aims of this study were to focus on and analyze the hematopoietic regulatory system on the basis of three aspects, specifically focusing on the effects of reactive oxygen. The first aim was to analyze the maintenance system of stem cells during the dormancy period and the system regulating their self-renewal during the cell cycle. The second aim was to examine the developmental termination of the cell cycle of hematopoietic stem cells and the molecular mechanisms related to hematopoietic kinetic changes during the developmental stage. The third aim was to examine changes in the cell-cycle fraction during the senescent stage with stress accumulation. As a result, a functionally different regulatory system was found to exist during stem cell differentiation, and a different regulatory mechanism during hematopoietic development is supposed to be present.