Analysis of mechanisms involved in multifunction of tumor invasion factor emmprin

肿瘤侵袭因子emmprin多功能机制分析

• 批准号: 20590415
• 负责人: NABESHIMA Kazuki
• 金额: $ 3万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590415/
• 关键词: 腫瘍; マトリックス・メタロプロテアーゼ; 浸潤; 転移

To analyze the mechanisms that are responsible for multifunction of emmprin, a tumor invasion-promoting factor, we induced crosslink among cell surface molecules by using a crosslinker BS3. The molecules, which had been crosskinked to emmprin, were analyzed by means of mass spectrometer. Up to now, the analysis has narrowed down to about 10 candidate molecules. Their abilities to complex with emmprin and stimulate fibroblasts to produce MMPs are now under investigation.

为了分析肿瘤侵袭促进因子emmprin的多功能机制，我们使用交联剂BS 3诱导细胞表面分子之间的交联。用质谱仪分析了与emmprin交联的分子。到目前为止，分析已经缩小到大约10个候选分子。它们与emmprin复合并刺激成纤维细胞产生MMPs的能力正在研究中。

项目成果

Emmprin is released as glycocalyceal bodies

Emmprin 作为糖萼体释放

• 发表时间: 2009
• 作者: Aoki M;Nabeshima K;et al.
• 通讯作者: et al.

Synthetic emmprin peptides inhibit tumor cell-fibroblast interaction-stimulated upregulation of MMP-2 and tumor cell invasion

• DOI: 10.3892/ijo.2011.1060
• 发表时间: 2011-09-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Koga, Kaori;Aoki, Mikiko;Nabeshima, Kazuki
• 通讯作者: Nabeshima, Kazuki

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts.

• DOI: 10.1186/1471-2407-11-300
• 发表时间: 2011-07-17
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Kawakami T;Sameshima T;Hojo H;Koga K;Nakahara Y;Toole BP;Suzumiya J;Okada Y;Iwasaki A;Nabeshima K
• 通讯作者: Nabeshima K

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