Analysis of mechanisms involved in multifunction of tumor invasion factor emmprin

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To analyze the mechanisms that are responsible for multifunction of emmprin, a tumor invasion-promoting factor, we induced crosslink among cell surface molecules by using a crosslinker BS3. The molecules, which had been crosskinked to emmprin, were analyzed by means of mass spectrometer. Up to now, the analysis has narrowed down to about 10 candidate molecules. Their abilities to complex with emmprin and stimulate fibroblasts to produce MMPs are now under investigation.