Functional analysis of Salmonella virulence factor involved in survival within host cells and systemic disease

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SpiC encoded within Salmonella pathogenicity island 2 on the Salmonella enterica serovar Typhimurium is involved in the expressions of FliC and FimA, which are a component of the flagellar filaments and a major subunit of type 1 fimbriae, respectively. Infection of macrophages with Salmonella causes the increase of intracellular Ca^<2+> levels in a SpiC-dependent manner and the elevation of Ca^<2+> activates the calcium signal transduction pathway, leading to the formation of Salmonella-induced filament that is involved in the intracellular survival of Salmonella.