Analysis of HDL dysfunction induced by oxidized phospholipids in atherosclerosis.

点击翻译按钮获取中文摘要

Oxidized LDL accumulates in macrophages, while HDL prevents the development of atherosclerosis. This study aimed at examining the relationship between oxidized phospholipids (PL) and impaired HDL function. We collected blood samples from hemodialysis (HD) patients, who have increased oxidative stress and high susceptibility to atherosclerosis. In the HD patients, serum PL concentration was low, but oxidized PL concentration and PL transfer activity increased significantly. In these patients, LCAT-dependent maturation of prebeta1-HDL, small HDL particles, was impaired. In summary, it is suggested that oxidized PL might be transferred from LDL to HDL, and cause impairment of HDL maturation.