Improved function of ketoamine oxidase for clinical examination reagent of diabetes by use of multiple approaches

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For prevention of diabetes, we should control of the concentration of glucose in our vessels. Since the concentration of glucose is affected by foods, the concentration of glycated proteins in vessels often became used as an indicator of the average of concentration of glucose. The ketoamine oxidase is crucial for the evaluation of the concentration of glucose from the glycated proteins. To improve the function of the ketoamine oxidase, we prepared many ketoamine oxidase mutants but did not obtain ketoamine oxidase mutant with improved function. Then, in order to obtain the basis for mutation design, we tried to analyze the three-dimensional structure of the ketoamine oxidase in vain.