Intake of Citrus Fruits associated with Atherosclerosis, Aging, and the Risk of Cardio-cerebro Vascular Disease.

我们进行了一项前瞻性队列研究。共有10，000名居住在社区的参与者，事先没有心血管疾病的诊断，完成了健康检查和食物频率调查表。在柑橘摄入量方面，旺季日摄入量与心血管疾病和死亡风险呈负相关，年平均日摄入量也是如此。风险曲线呈U型。因此，我们认为有上限的适当摄入量为米坎。此外，当65岁的参与者具有相当的认知功能时，如果他们的超声测量的颈动脉粥样硬化更强，则5年后这些功能的下降更多。总之，预防动脉粥样硬化直到65岁是重要的。

We conducted a prospective cohort study. A total of 10,000 participants living in communities, free of prior diagnosis of cardiovascular disease completed health check-up examination and food frequency questionnaire. About intake of mikan (mandarin oranges), daily intake of high season was negatively associated with risk of cardiovascular disease and mortality as was daily intake of annual average. Further we found U-shaped risk curve. Therefore we thought there were upper limit of adequate intake for mikan. In addition, when participants of 65 years old had a cognitive function comparable, if their atherosclerosis of carotid artery by ultrasound measurement were stronger, there was more decrease of those function at 5 years later. In conclusion, prevention of atherosclerosis up to 65 years oldwas important.