Differences of the effect of colonic carcinogenesis by various kinds of fatty acids

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We investigated whether various dietary fats affected the colon mucosal growth and tumorigenesis in azoxymethane-treated rats. Rats were supplemented with 10% corn, olive, beef, and fish oil for 44 weeks. Long-term dietary corn oil and beef tallow increased tumor incidence with increased BrdU incorporation. In contrast, both olive and fish oil inhibited them. BrdU-incorporated cells were often observed at tops of crypts in rats fed with beef tallow. Long-term high intake of corn oil and beef tallow enhanced cell proliferation and modulated distribution of proliferating cells, which might contribute to promoting effect in colon tumorigenesis.