Differences of the effect of colonic carcinogenesis by various kinds of fatty acids

各种脂肪酸致癌作用的差异

• 批准号: 20590745
• 负责人: RYUICHI Iwakiri
• 金额: $ 2.91万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590745/
• 关键词: 大腸癌; 脂肪摂取; 脂肪酸; Wnt signaling; 酸化ストレス; 共役脂肪酸; Wntシグナル; アラキドン酸カスケード; 共役リノール酸; 発癌抑制; アポトーシス; COX-2; 飽和脂肪酸; 細胞増殖

We investigated whether various dietary fats affected the colon mucosal growth and tumorigenesis in azoxymethane-treated rats. Rats were supplemented with 10% corn, olive, beef, and fish oil for 44 weeks. Long-term dietary corn oil and beef tallow increased tumor incidence with increased BrdU incorporation. In contrast, both olive and fish oil inhibited them. BrdU-incorporated cells were often observed at tops of crypts in rats fed with beef tallow. Long-term high intake of corn oil and beef tallow enhanced cell proliferation and modulated distribution of proliferating cells, which might contribute to promoting effect in colon tumorigenesis.

我们研究了各种膳食脂肪是否影响氧化偶氮甲烷处理大鼠的结肠粘膜生长和肿瘤发生。大鼠补充10%的玉米，橄榄，牛肉和鱼油44周。长期饮食玉米油和牛脂增加肿瘤发病率增加BrdU掺入。相反，橄榄油和鱼油都抑制它们。在饲喂牛脂的大鼠中，经常在隐窝顶部观察到BrdU掺入细胞。长期高摄入玉米油和牛脂可促进细胞增殖，并调节增殖细胞的分布，这可能是其促进结肠肿瘤发生的一种机制。

项目成果

NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients: Evaluation by a case-control study

• DOI: 10.1111/j.1440-1746.2010.06610.x
• 发表时间: 2011-06-01
• 期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 4.1
• 作者: Tsuruoka, Nanae;Iwakiri, Ryuichi;Fujimoto, Kazuma
• 通讯作者: Fujimoto, Kazuma

Suppression of intestinal mucosal apoptosis by ghrelin in fasted rats.

胃饥饿素对禁食大鼠肠粘膜细胞凋亡的抑制作用。

• 发表时间: 2008
• 期刊: Exp Biol Med 233
• 作者: Park JM;Kakimoto T;Kuroki T;Shiraishi R;Fujise T;Iwakiri R;Fujimoto K.
• 通讯作者: Fujimoto K.

Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats

• DOI: 10.1038/cr.2009.97
• 发表时间: 2009-08
• 期刊: Cell Research
• 影响因子: 44.1
• 作者: Bin Wu;Lixian Zeng;Ying Lin;Zhuofu Wen;Guihua Chen;R. Iwakiri;K. Fujimoto

Azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling and the effects of the olive oil.(Olives and Olive Oil in Health and Disease Prevention, edited by Preedy VR and Watson RR.)

偶氮甲烷通过 Wnt/β-连环蛋白信号传导和橄榄油的作用诱导结肠癌发生。（健康和疾病预防中的橄榄和橄榄油，由 Preedy VR 和 Watson RR 编辑。）

• 发表时间: 2010
• 作者: Fujise T;Iwakiri R;Shiraishi R;Wu B;Fujimoto K
• 通讯作者: Fujimoto K

ENDOSCOPIC HEMOSTASIS WITH METALLIC HEMOCLIPS FOR IATROGENIC MALLORY‐WEISS TEAR CAUSED BY ENDOSCOPIC EXAMINATION

金属止血夹内镜止血治疗内镜检查引起的医源性马洛里-韦斯撕裂

• DOI: 10.1111/j.1443-1661.2008.00825.x
• 发表时间: 2009
• 期刊: Digestive Endoscopy
• 影响因子: 5.3
• 作者: R. Shimoda;R. Iwakiri;Hiroyuki Sakata;S. Ogata;H. Ootani;Y. Sakata;T. Fujise;Kanako Yamaguchi;Kotaro Mannen;Seichiro Arima;Ryosuke Shiraishi;T. Noda;A. Ono;S. Tsunada;K. Fujimoto
• 通讯作者: K. Fujimoto