Mechanisms of Mallory body formation and elimination in hepatocytes

malory - denk小体（MDB）的形成与细胞内蛋白质降解系统的异常有关。蛋白酶体和自噬都与MDB的形成有关。内质网应激和氧化应激与MDB的形成有关。MDB的形成可能是对这些压力的适应性反应。调节自噬是包涵体相关疾病包括各种肝脏疾病的治疗策略之一。

Formation of Mallory-Denk bodies (MDB) was associated with abnormality of the intracellualr protein degradation system. Both proteasome and autophgy were associated with MDB formation. Endoplasmic reticulum stress and oxidative stress were related with MDB formation. MDB formation may be an adaptive response to these stresses. Modulation of autophagy was one of the therapeutic strategies of inclusion body-associated diseases including various liver diseases.