Engineering of biological pacemaker with autonomic innervation

本研究表明，神经营养因子在交感神经元对心肌细胞的轴突导向中起重要作用。结果表明，适当使用神经营养因子可以使移植的心肌细胞自主神经支配。因此，该技术可能是在心肌再生治疗中工程化功能心肌的重要一步。

The present study showed that neurotrophic factors play important roles in axon guidance of sympathetic neurons to cardiomyocytes. The results suggest that appropriate use of neurotrophic factors enable autonomic innervations in transplanted cardiomyocytes. Thus, the technique may be an important step to engineer functional myocardium in myocardial regeneration therapy.