Identification and characterization of proteins bound to MURC which is involved in cardiac dysfunction and arrhythmia
Identification and characterization of proteins bound to MURC which is involved in cardiac dysfunction and arrhythmia
批准号:
20590863
负责人:
UEYAMA Tomomi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
我们发现MURC定位于心肌细胞质膜上的小窝,MURC与小窝蛋白-3、PTRF/Cavin-1、SDPR/Cavin-2和SRBC/Cavin-3相关。我们还发现,在心肌细胞中过表达MURC会导致小窝扩张,而在心脏中表达MURC的转基因小鼠则表现出心肌细胞中小窝的变形。
英文摘要
We found that MURC was localized to caveolae at the plasma membrane of cardiomyocytes, and that MURC was associated with caveolin-3, PTRF/cavin-1, SDPR/cavin-2, and SRBC/cavin-3. We also found that overexpression of MURC in cardiomyocytes induced distension of caveolae and transgenic mice expressing MURC in the heart exhibited deformation of caveolae in cardiomyocytes.
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DOI:
10.1371/journal.pone.0009746
发表时间:
2010-03-18
期刊:
PloS one
影响因子:
3.7
作者:
[Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Ueyama T, Oh H, Matsubara H]
通讯作者:
Matsubara H
Serglycin, a novel adipokine highly expressed in epicardial adipose tissue.
Serglycin,一种在心外膜脂肪组织中高表达的新型脂肪因子。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Imoto H, Takahashi T, Adachi A, Nakanishi N, Kangawa H, Ueyama T, Matsubara H]
通讯作者:
Matsubara H
DOI:
10.1016/j.bbrc.2007.11.087
发表时间:
2008-01-25
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Nomura, Tetsuya, Ueyama, Tomomi, Oh, Hidemasa]
通讯作者:
Oh, Hidemasa
A novel but evolutionarily conserved muscle-restricted coiled-coil protein, MURC, regulates myogenic differentiation in C2C12 cells.
MURC 是一种新型但进化上保守的肌肉限制性卷曲螺旋蛋白,可调节 C2C12 细胞的肌原性分化。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tagawa M, Ueyama T, Ogata T, Nakajima N, Isodono K, Asada S, Takehara N, Takahashi T, Matsubara Hiroaki, Oh H.]
通讯作者:
Oh H.
MURC, Muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes.
MURC,肌肉限制性卷曲螺旋蛋白,调节小凹形态并诱导心肌细胞肥大。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Taniguchi T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Amano K, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Morimoto M, Takahashi T, Oh H, Ueyama T, Matsubara H.]
通讯作者:
Matsubara H.
共 17 条
Elucidation of MURC-mediated mechanisms of caveolae function and transportsome formation in cardiomyocytes
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批准号:23591088
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
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负责人:UEYAMA Tomomi
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依托单位:
Molecular cloning and characterization of differentiation-inducing factors into the cardiac myocyte lineage using an expression cloning approach
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批准号:18590773
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
-
财政年份:2006
-
负责人:UEYAMA Tomomi
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依托单位:
海外基金