Analysis of functional EPC for the treatment of ischemic disease

我们以前曾报道ALDH-Low EPC具有缺氧反应。在这项研究中，我们研究了缺氧诱导因子（HIF）是如何参与修复缺血组织在小鼠皮瓣模型。HIF-2 α而不是HIF-1 α与缺血时组织损伤的减少高度相关。最后，我们发现HIF靶基因VEGF和CXCR 4在缺血组织的新生血管形成中具有重要作用。

We have reported previously that ALDH-Low EPC possess hypoxic response. In this study, we examined how hypoxia-inducible factor (HIF) is involved in the repair of ischemic tissue in a mouse flap model. HIF-2alpha but not HIF-1alpha was highly associated with the reduced tissue damage in ischemia. Finally, we found that HIF-target genes, VEGF and CXCR4, have an important role for the neovascularization in ischemic tissue.