Study for the pathogenesis of pulmonary emphysema induced by cigarette smoking using newly developed transcription factor MafB gene targeted mouse.

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We generated the macrophage scavenger receptor enhancer-promoter dominant negative (DN) MafB TG mice that could repress MafB transcription activity only in macrophages. In this TG mouse, alveolar macrophages decreased, possibly due to enhanced apoptosis. Furthermore, the alteration of cell shapes and the reduction of phagocytic capacity were observed in this TG mouse. This study revealed that the various in vivo role of transcription factor MafB, such as suppression of apoptosis, maintenance of cell shape, and regulation of phagocytic function.