Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockade

我们确定了27个基因抑制的封锁AP-1，致癌转录因子，在肺癌细胞敏感的AP-1封锁使用微阵列分析。其中，通过siRNA敲低DNA复制许可复合物的组分MCM 4降低了多种肺癌细胞的细胞生长。手术切除的肺癌中的免疫组化分析表明，MCM 4表达与增殖标记物包括Ki-67相关。MCM 4可能在肺癌的生长过程中起重要作用，有望成为肺癌治疗的新靶点。

We identified 27 genes suppressed by blockade of AP-1, an oncogenic transcription factor, in lung cancer cells sensitive to the AP-1 blockade using microarray analysis. Among them, knockdown of MCM 4, a component of DNA replication licensing complex, by siRNA reduced cell growth in multiple lung cancer cells. Immunohistochemical analysis in surgically resected lung cancers demonstrated that MCM4 expression was correlated with proliferation markers including Ki-67. MCM4 may play an important role for growth of lung cancers and be a novel molecular target for lung cancer.