Co-analysis of multi-gene polymorphisms related to future development of asthma

呼吸道高反应性(AHR)是哮喘的一个标志。一些没有呼吸道症状的年轻特应性成人表现出AHR，他们和那些儿童哮喘缓解期的人一起构成了成人哮喘的可能风险组。本研究提出表皮生长因子受体(EGFR)和蛋白水解酶激活受体(PAR)-1基因多态性可能与这些危险群体的形成有关。

Airway hyperresponsiveness (AHR) is a hallmark of bronchial asthma. Some of young atopic adults without respiratory symptoms exhibit AHR, and they as well as those with a remission of childhood asthma constitute a possible risk group for adult-onset asthma. The present study raised the possibility that gene polymorphism of epidermal growth factor receptor (EGFR) and protease activated receptor (PAR)-1 might be associated with the formation of these risk groups.