the research related to the pathogenesis and novel treatment of pulmonary hypertension making use of genetically-modified mouse

为了研究CD4/CD8 T细胞在肺动脉高压（PH）发病机制中的作用，我们评估了单氯胆碱（MCT）诱导的CD4或CD8缺陷小鼠和野生型小鼠的肺部炎症和右心室肥厚（RVH）的严重程度。在所有mct诱导组中均观察到肺炎症反应，然而，RVH仅在野生型小鼠中观察到，CD4-和CD8-缺失小鼠均未观察到。从所有这些结果来看，CD4和CD8 T细胞群可能与肺动脉高压的发生有关。

To study the role of CD4/CD8 T cell in the pathogenesis of pulmonary hypertension (PH), the severity of lung inflammation and right ventricular hypertrophy(RVH) was evaluated in monocrotaline(MCT)-induced CD4- or CD8- deficient mice as well as wild-type mice. The inflammation responses in lung were observed in all MCT-induced groups, however, RVH were only observed in wild -type mice, not CD4- nor CD8- deficient mice. From all these results, CD4 and CD8 T cell groups might be associated with the development of pulmonary hypertension.