Effect of genetic variation of IL-13 on airway remodeling in Bronchial asthma

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We have demonstrated asthmatic patients with genetic variants of IL-13 Q110/Q110 (homozygous for glutamine) are significantly associated with a reduced pulmonary function in Japanese patients. An increased the protein level of IL-13, IL-23, IL-11, GM-CSF, hyaluronic acid, and CCL8/MCP-2 in bronchial lavage fluid were shown. We have observed that the subepithelial layer was significantly thicker in the biopsy samples taken from the patients with Q110/Q110 compared to wild type individuals. Our study demonstrates that Q110/Q110 increases, at least in part, allergic inflammation and the propensity for airway remodeling, thus resulting in low lung function.