Role of SOD in the pathogenesis of diabetic nephropathy

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Superoxide dismutase (SOD) is a major anti-oxidant enzyme which scavenges superoxide anion. In the present study, we found that SOD is down-regulated in the kidneys of diabetic mice susceptible to nephropathy, leading to renal superoxide overproduction. Furthermore, we demonstrated that SOD mimetic dramatically prevents the progression of diabetic nephropathy in these mice via reducing renal superoxide production. We conclude that SOD plays an important role in preventing renal damage by oxidative stress inducing under chronic hyperglycemia.