The structural biological study of the macromolecular complex involved with formation of SARS-CoV virions

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The aim of this study is elucidating the molecular basis of budding of SARS coronavirus (SARS-CoV). In the initiation stage of a budding of virion from infected host cell, N protein and M protein are interacted. This interaction is considered as a trigger of budding of SARS-CoV. To obtain a detail of the molecular mechanism of this phenomenon, I tried to solve the crystal structure of the macromolecular complex of N and M proteins and established the preparation method of N protein.