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Study of functional and physical interactions between an amino acid transporter complex LAT1-4F2hc and Integrin by using Reconstituted proteoliposomes

Study of functional and physical interactions between an amino acid transporter complex LAT1-4F2hc and Integrin by using Reconstituted proteoliposomes
使用重组蛋白脂质体研究氨基酸转运蛋白复合物 LAT1-4F2hc 和整合素之间的功能和物理相互作用
批准号:
20770101
负责人:
NAGAMORI Shushi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
LAT1(L-type amino acid transporter 1) is one of the transporters which uptake essential amino acids. Expression of the function requires an interacting partner, CD98/4F2hc. In this study, a new experimental system has been developed to study LAT1-function in detail and it is shown that CD98/4F2hc is not essential for the function. Furthermore, Annexine II was identified as a CD98/4F2hc -binding protein beside integrin.
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会议论文
A novel role of the C-terminus of b0, +AT in the ER-Golgi trafficking of the rBAT-b0, +AT heterodimeric amino acid transporter.
b0、AT C 末端在 rBAT-b0、AT 异二聚体氨基酸转运蛋白的 ER-高尔基体运输中的新作用。
DOI: --
发表时间: 2009
期刊: Biochem J. 417
影响因子: --
作者: [Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.]
通讯作者: Kanai Y.
Substrate recognition of L-type amino acid transporter 1, LAT1, and transport kinetics of its PET ligand L-[3-F]-α-methyltyrosine, FAMT
L 型氨基酸转运蛋白 1 (LAT1) 的底物识别及其 PET 配体 L-[3-F]-α-甲基酪氨酸 (FAMT) 的转运动力学
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [永森収志, 他]
通讯作者:
A novel role of C-terminus of b^<0,+>AT in the ER-Golgi trafficking of rBAT-b^<0,+>AT heterodimeric amino acid transporter.
b^<0,>AT C 末端在 rBAT-b^<0,>AT 异二聚体氨基酸转运蛋白的 ER-高尔基体运输中的新作用。
DOI: --
发表时间: 2009
期刊: Biochem J 15
影响因子: --
作者: [Sakamoto, 他]
通讯作者:
DOI: 10.1016/j.canlet.2008.10.035
发表时间: 2009-04-08
期刊: CANCER LETTERS
影响因子: 9.7
作者: [Yamauchi, Kohichi, Sakurai, Hiroyuki, Kohno, Naoyuki]
通讯作者: Kohno, Naoyuki
17
    Identification and the physiological role of a cystine transporter
    • 批准号:
      24591198
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      NAGAMORI Shushi
    • 依托单位:
    Basic study for treatment of Japanese type of Cystinuria by peptidomimetic drugs
    • 批准号:
      22790789
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      NAGAMORI Shushi
    • 依托单位:
    海外基金