Analysis of the molecular mechanism regulating target gene selection

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During vertebrate development, the same signaling molecule is often expressed repeatedly and plays an important role in each time and place. This means the same signal can differently regulate the expression of genes in each case. This differential control of gene expression is probably caused by differential competence of the cells in response to signals. In this research, we will analyze the phenotype of zebrafish mutants which are defective for the differential control of gene expression and identify their responsible genes, and try to understand the molecular mechanism underlying the differential competence.