A novel network regulating the expression of PCB deRradation Renes.

多氯联苯降解基因jostii Rhodococcus RHA1在联苯存在时被激活表达。这种激活在下游途径中出现的中间代谢物的存在中受到抑制。在这项研究中。我们发现儿茶酚是导致这种抑制的代谢物。通过使邻苯二酚的代谢通量平稳，可以构建出具有稳定降解活性的PCB降解体。

The expression of polychlorinated biphenyls degradation genes in a PCB degrader, Rhodococcus jostii RHA1, is activated in the existence of biphenyl. This activation is repressed in the existence of intermediate metabolites which appear in the downstream pathway. In this study. we revealed that catechol is the metabolite which causes this repression. By making the metabolism flux from catechol smoothly, a PCB degrader which gives the constant degradation activity can be constructed.