The bacterial controls using antimicrobial peptides from complement components of fish

结果表明，合成的与鲤鱼C3同型（C3- q1） C3a区部分氨基酸序列对应的肽段（KVFLECCNLMKTHKNMKTE）具有抗菌作用，并对革兰氏阴性菌大肠杆菌有作用。（XL1-Blue mrf和O157:H7 (VT1和VT2)）和s.e enteritidis。我们成功地通过部分替换上述序列的氨基酸来增强抗菌活性。然而，抗菌活性的增强导致了高的细胞毒活性。今后，我们的目标是在本研究观察的基础上，创造低副作用的抗菌肽。

Our results revealed that the synthetic peptide corresponding to partial amino acid sequence (KVFLECCNLMKTHKNMKTE) of C3a region of carp C3 isotype (C3-Q1) was antibacterial, and acted on Gram-negative bacteria, Escherichia coli. (XL1-Blue mrf and O157:H7 (VT1 and VT2)) and S.Enteritidis. We successfully enhanced antibacterial activity, by partially replacing amino acids of above-mentioned sequence. However, it was found that enhancement of antibacterial activity led to high cytotoxic activity. Hereafter, we aim to create antimicrobial peptides with low side effects on the basis of observation in this study.