Insulin signaling and lipid metabolism in fish

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We cloned several genes possibly involved in lipid metabolism from torafugu and red seabream, and showed that their transcripts were predominant in tissues containing high quantities of lipid. Changes in expression of these genes suggested that lipid is transported mainly from liver to muscle in torafugu under starved conditions, whereas from adipose tissues to muscle in red seabream. cDNAs encoding hormones and their downstream signaling molecules related to lipid metabolism were also cloned and analyzed for their expression and tissue distribution.