Synthesis of new seco-steroidal compounds, their use for steroidal biological evaluation, and development of new drug candidates

本课题通过合成化学修饰，合成并稳定分离了14-表普维他明D3类似物，作为新的二次甾体化合物。利用这些新的类似物，我对它们的生物学性质进行了评价，发现了一种新的用于治疗骨质疏松症的先导化合物。此外，我还获得了评估它们非基因组作用的初步结果。通过对19-甲基的去除，我发现了前维他明D3异构化为速尿甾醇骨架，这可能是一个新的候选药物。

In this project, I have synthesized and stably isolated the 14-epi-previtamin D3 analogs as new seco-steroidal compounds by synthetic chemical modification. Using these new analogs, I evaluated their biological properties, and have found a new lead compound for osteoporosis drug. Also, I was able to have preliminary results for the evaluation of their nongenomic action. By the removal of 19-methyl group, I have discovered the isomerization from previtamin D3 to tachysterol skeleton, which could be a new drug candidate.