Approach to PET cancer screening : developments of low molecule probe tagged gallium-68 and carbon-11labeling method

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I paid attention to the positron-emitting radionuclide, especially gallium-68 and carbon-11, and developed the following reactions using an unstable chemical species such as aryne and radical for the label based on high-speed reactions. In addition, I developed the oxidation-reduction reaction using the photocatalyst for capture of CO_2.First, to develop gallium-68 probe, I studied aryne based Huisgen-type reaction under the metal-free condition and desired benztriazole was obtained in excellent yield. I also reported the [2+2] type reaction, insertion of aryne into the C=O π-bond of formamides, and the subsequent trapping process of the benzoxetene intermediate with dialkylzincs. In addition, under mild condition, I reported the multi-component coupling reaction leading chromenes, coumarins and xanthenes via the insertion into π-bond of DMF. Moreover, I reported the cascade addition-cyclization-trapping reaction involving the unfavorable mismatched interaction of nucleophilic radicals, together with the control of enantioselectivities. And I reported the results of experiments to prove the utility of the polycrystalline TiO_2 (P25) in the hydrogenation of aromatic ketones.