The mechanism of dephosphorylation of CERT by the reduction of raftcomponents

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It is known that CERT (ceramide transport protein) is activated by the dephosphorylation, which is triggered by the degradation of plasma membrane sphingomyelin or by the treatment of inhibitor for sphoingomyelin synthesis. Our research elucidated these two dephosphorylation pathway is qualitatively different. Additionally, a novel phosphorylation site of CERT was found unexpectedly, and the phosphorylation of this site had a significant effect on the previously reported multiple phosphorylation of CERT. The results suggest that the activity of CERT is regulated by more complicated, multi-step mechanism.