Development of new therapy of steatohepatitis by Clostridium Butyricum
Development of new therapy of steatohepatitis by Clostridium Butyricum
批准号:
20790131
负责人:
NAGATA Naoto
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
We tested to treat atherogenic-diet (high cholesterol diet) induced steatohepatitis in mice by Clostridium Butyricum. After 4, 8, 16, and 32 weeks treatment, the atherogenic diet-induced steatosis, inflammation, and fibrosis were improved in the mice liver. We demonstrated that butyrate up-regulates fatty acid beta oxidation via activation AMP activated protein kinase and histone acetylation in vitro. Clostridium Butyricum may improve non-alcoholic steatohepatitis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
腸内細菌由来の生理活性物質である短鎖脂肪酸はAMPキナーゼを活性化させる、中 川ゆうみ
短链脂肪酸,源自肠道细菌的生理活性物质,激活 AMP 激酶,中川由美
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[長田直人, 澤本一樹, 太田嗣人, 横山将嘉, 高山浩昭, 熊崎雅史, 野田浩代, 北出紘規, 松本優香子, 御簾博文, 篁俊成, 金子周一, 宮本謙一]
通讯作者:
宮本謙一
Impacts of protein tyrosine phosphatase Shp2 on liver inflammation
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批准号:25860526
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2013
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负责人:NAGATA Naoto
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依托单位:
Molecular actions of anesthetic drugs : Differential modulation by polymorphic forms of protein kinase C.
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批准号:06807123
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1994
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负责人:NAGATA Naoto
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依托单位:
海外基金