Interaction of nucleoside transport and drug transport in placental trophoblast cells at various stages of pregnancy

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Standard methods of drug administration to pregnant woman have not been established. The purpose of this study was to clarify the interactions of nutrient and drug transport mechanisms in the placenta in order to establish safe, effective, and rational treatment methods for pregnant woman. We also aimed to clarify the transport mechanisms of drugs and nutrients in placenta under pathological conditions. As the supply of nucleosides is important for fetal growth, we focused on the interaction of transport mechanisms for drugs and nucleosides in the placenta. The uptake mechanisms of nucleosides in placenta in gestational diabetes was also clarified. These results should be useful for the establishment of standard methods of drug administration for the pregnant woman.