Optimization of nasal administering conditions with the formulation development.

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In order to establish the evaluation system to optimize the nasal formulation, drug absorption from the powder formulations following nasal administration was investigated. The balance of the nasal residence of the drug and the dissolution from powder in the nasal cavity was an important factor to determine the nasal drug absorption. This finding suggested the feasibility that the nasal absorption is improved by controlling the nasal residence time of powder formulation. On the other hand, it was clarified that the transcellular permeability of the drug is dependent on the origin of the cell used for in vitro study. This finding would lead to renewing and improving the estimation system for nasal drug absorption, which had been previously established.