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Elucidation of molecular mechanisms of gliogenesis and an attempt to induce neurogenesis in the adult spinal cord

Elucidation of molecular mechanisms of gliogenesis and an attempt to induce neurogenesis in the adult spinal cord
阐明胶质细胞生成的分子机制并尝试诱导成人脊髓神经发生
批准号:
20790161
负责人:
KITADA Masaaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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相关文献

中文摘要
翻译
我们发现室管膜细胞作为神经胶质前体细胞在成人脊髓中具有活性。在本研究中,我们阐明了室管膜细胞的增殖和分化受Notch通路细胞内信号的调控。此外,我们还探索了将这种胶质细胞形成转化为神经发生的可能性,从而确定了调节胶质细胞形成和神经发生的因子。
英文摘要
We have found the activity of the ependymal cells as glial precursor cells in the adult spinal cord. In this study, we elucidated that proliferation and differentiation of the ependymal cells are regulated by the intracellular signaling of Notch pathway. Also, we explored the possibility to convert this gliogenesis into neurogenesis and thus identified the factor which can regulate gliogenesis and neurogenesis.
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会议论文
DOI: 10.1038/jcbfm.2009.62
发表时间: 2009-08-01
期刊: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
影响因子: 6.3
作者: [Hayase, Makoto, Kitada, Masaaki, Dezawa, Mari]
通讯作者: Dezawa, Mari
Unique multipotent stem cells in adult human mesenchymal cell populations.
成人间充质细胞群中独特的多能干细胞。
DOI: --
发表时间: 2010
期刊: Proc Natl Acad Sci U S A 107(19)
影响因子: --
作者: [Kuroda Y*, Kitada M*, et al (+14 people)]
通讯作者: et al (+14 people)
DOI: 10.1073/pnas.0911647107
发表时间: 2010-05-11
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Kuroda, Yasumasa, Kitada, Masaaki, Dezawa, Mari]
通讯作者: Dezawa, Mari
Notch regulation of the spinal progenitor fate in the adult rodent.
成年啮齿动物脊髓祖细胞命运的缺口调节。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Kitada M, Dezawa M]
通讯作者: Dezawa M
共 22 条
    The identification of the gene locus applicable to gene recombination technology in Xenopus
    Neurogenesis in the adult spinal cord by cell fate control
    • 批准号:
      22790181
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      KITADA Masaaki
    • 依托单位:
    海外基金