Molecular mechanism of synapsis checkpoint in mammalian meiosis

点击翻译按钮获取中文摘要

Meiosis is a special type of cell division producing oocytes and sperms. The failure in the process of meiosis causes infertility and miscarriage in human reproduction. To avoid such problems, there is a surveillance mechanism called meiotic checkpoint, although its molecular mechanism has been totally unknown, especially in mammals. In this study, the function of a meiosis-specific gene HORMAD1 was analyzed by generating gene-targeted mice. As a result, HORMAD1 was identified as the first gene required for the meiotic checkpoint in mammals.