Physiological analysis of novel orphan GPCR involved in energy homeostasis

点击翻译按钮获取中文摘要

Drosophila orphan GPCR, bride of sevenless (BOSS) responds to extracellular glucose and regulates sugar and lipid metabolism. BOSS is evolutionally conserved from fly to human. In mammal, four homologues of BOSS, GPRC5A, GPRC5B, GPRC5C, and GPRC5D, exist. However, their molecular and physiological functions remain unclear. Here, we describe the role of GPRC5B in the regulation of energy homeostasis. GPRC5B was expressed highly in the brain and adipose tissue. GPCR5B-deficient mice showed decreased weight gain compared with wild type mice, despite of the similar food intake. This phenotype was attributed to increased oxygen consumption, but not increased physical activity.