WANIAR4 ( M) Development of the animal model for postpartum psychosis and the elucidation of pathogenic mechanisms through estrogen action

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We found that primiparous rats at 3 weeks-postpartum showed increased anxiety and depressive behaviors in elevated plus maze (EP) and forced swimming (FS) tests, compared with diestrus nulliparous females. ERa-selective agonist and estrogen displayed anxiolytic and antidepressant effects in EP and FS tests at 3 weeks-postpartum after subcutaneous injection once daily for 4 days. Furthermore, we found a marked alteration in the expression of TrkB and BDNF (brain-derived neurotrophic factor) receptors, and in resultant intracellular signaling of the 3 weeks-postpartums. This raises a possibility that changes of neurotrophin signaling via ERa stimulation are associated with anxiety and depression-like behaviors. In couclusion, we identified an animal model of postpartum psychosis and postpartum depression, which could be employed to develop innovative drugs of ERa stimulant for these diseases.