Role of inositol 1, 4, 5-trisphosphate in the maintenance of the function of cerebellar Bergmann glia

突触是神经元之间的连接点。突触功能的维持对成人大脑中稳定的神经元信息处理至关重要。伯格曼神经胶质细胞表达谷氨酸转运蛋白，这种转运蛋白能迅速将谷氨酸从细胞外空间移除，并在小脑突触传递的精确操作中发挥关键作用。我们发现由肌醇1,4,5-三磷酸组成的信号级联参与谷氨酸转运蛋白的表达以维持谷氨酸清除的能力。因此，1,4,5-三磷酸肌醇对维持突触功能至关重要。

Synapse is a connecting point between neurons. The maintenance of synaptic functions is essential for stable neuronal information processing in the adult brain. Bergmann glial cells express glutamate transporters that rapidly remove glutamate from the extracellular space, and play a critical role in the precise operation of synaptic transmission in the cerebellum. We found that a signaling cascade comprising inositol 1,4,5-trisphosphate is involved in glutamate transporter expression to maintain the capacity of glutamate clearance. Thus, inositol 1,4,5-trisphosphate is essential for the maintenance of synaptic function.