Regulation of cell polarity by a novel Par3-binding protein

细胞极化在发育的各种过程中是至关重要的。在几种类型的细胞中，需要Par3/Par6/aPKC(PAR APKC)复合体来建立极性。在这一过程中，PAR-aPKC复合体靶向于细胞膜，在细胞极化过程中起着重要作用。然而，人们对该复合体的亚细胞定位机制知之甚少。在本研究中，我们鉴定了一种新的Par3结合蛋白，它将PAR aPKC复合体招募到质膜上，以调节哺乳动物上皮细胞的极性。

Cell polarization is crucial for a variety of processes in development. The Par3/Par6/aPKC (Par aPKC) complex is required for polarity establishment in several types of cell. During the process, the Par aPKC complex is targeted to the plasma membrane, which plays an important role in cell polarization. However, little is known about the mechanisms underlying proper subcellular localization of the complex. In the present study, we identify a novel Par3-binding protein, which recruits the Par aPKC complex to the plasma membrane for regulating mammalian epithelial cell polarity.