Role of Spred/Sprouty in angiogenesis and lymphangiogenesis

Sprouty/Spred家族蛋白负向调控生长因子和细胞因子激活的ERK信号。我们分析了这个家族的基因敲除小鼠，发现Sproutys负调控血管生成，而Spreds负调控淋巴管生成。Sprouty4抑制血管内皮生长因子- a （VEGF-A）诱导的ERK活化，而Spred1/2有效抑制淋巴管生成所必需的VEGF-C。我们已经确定了Sproutys和Spreds之间的区别。vegf信号转导的作用我们还发现人类SPRED1与I型神经纤维瘤病相关。

Sprouty/Spred family proteins negatively regulate ERK signaling activated by growth factors and cytokines. We have analyzed gene knockout mice of this family and found that Sproutys negatively regulate angiogenesis, while Spreds regulate lymphangiogenesis. Sprouty4 inhibits vascular endothelial growth factor-A (VEGF-A) induced ERK activation, while Spred1/2 efficiently inhibit VEGF-C, which is essential for lymphangiogenesis. We have identified the difference between Sproutys and Spreds.in the action of VEGFs signal transduction. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease.