Role of Spred/Sprouty in angiogenesis and lymphangiogenesis

Spred/Sprouty 在血管生成和淋巴管生成中的作用

• 批准号: 20790241
• 负责人: KATO Reiko
• 金额: $ 2.75万
• 依托单位: National Institute of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790241/
• 关键词: 血管; リンパ管; Ras; ERK; シグナル; チロシンキナーゼ; プロテインキナーゼC; VEGF; G-CSF; ホスフォイノシタイド; ノックアウトマウス; 負の制御; フォスフォリパーゼC; G-CSE

Sprouty/Spred family proteins negatively regulate ERK signaling activated by growth factors and cytokines. We have analyzed gene knockout mice of this family and found that Sproutys negatively regulate angiogenesis, while Spreds regulate lymphangiogenesis. Sprouty4 inhibits vascular endothelial growth factor-A (VEGF-A) induced ERK activation, while Spred1/2 efficiently inhibit VEGF-C, which is essential for lymphangiogenesis. We have identified the difference between Sproutys and Spreds.in the action of VEGFs signal transduction. We also found that human SPRED1 is responsible for neurofibromatosis type I like disease.

Sprouty/Spred家族蛋白负调节由生长因子和细胞因子激活的ERK信号传导。我们分析了这个家族的基因敲除小鼠，发现Sproutys负调节血管生成，而Spreds调节淋巴管生成。Sprouty 4抑制血管内皮生长因子-A（VEGF-A）诱导的ERK激活，而Spread 1/2有效地抑制VEGF-C，这是淋巴管生成所必需的。我们已经确定了Sproutys和Spreds.in之间的差异VEGF信号转导的作用。我们还发现，人SPRED 1是负责神经纤维瘤病I型样疾病。

项目成果

FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

• DOI: 10.1182/blood-2008-05-159848
• 发表时间: 2008-12-01
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Miyamoto, Kana;Miyamoto, Takeshi;Suda, Toshio
• 通讯作者: Suda, Toshio

FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress of aging.

FoxO3a 在衰老应激条件下通过负反馈途径调节造血稳态。

• 发表时间: 2008
• 期刊: Blood 112
• 作者: Miyamoto K;Miyamoto T;Kato R
• 通讯作者: Kato R

Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.

• DOI: 10.1371/journal.pone.0005467
• 发表时间: 2009
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Taniguchi K;Sasaki K;Watari K;Yasukawa H;Imaizumi T;Ayada T;Okamoto F;Ishizaki T;Kato R;Kohno R;Kimura H;Sato Y;Ono M;Yonemitsu Y;Yoshimura A
• 通讯作者: Yoshimura A

Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis

• DOI: 10.1038/onc.2008.464
• 发表时间: 2009-02-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Ayada, T.;Taniguchi, K.;Yoshimura, A.
• 通讯作者: Yoshimura, A.