LKB-1, K-ras, and EGFR gene mutation involvement in the multistep tumorigenesis of primary lung adenocarcinomas

在目前的研究中，我们发现了一例原发性肺腺癌，免疫组织化学证实其碱性磷酸酶异常。肿瘤呈支气管腔内息肉样生长，伴有周围肺组织侵犯。近年来，ALK基因异常的肺癌在治疗方面引起了越来越多的关注，即ALK抑制剂治疗。本病例为首例ALK免疫阳性肺癌，提示中央支气管表面上皮细胞起源。

In the present study, we detected a case of primary pulmonary adenocarcinoma with an immunohistochemically proven ALK abnormality. The tumor showed an endobronchial polypoid growth pattern with peripheral pulmonary tissue invasion. Recently, lung cancers having ALK gene abnormalities have attracted growing attention because of therapeutic aspects, i.e., ALK inhibitor therapies. The present case is the first case of ALK-immunopositive lung cancer suggesting central bronchial surface epithelial origin.