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The relationship of the expression of the neuronal intermediate filaments and clinical behavior of gastroenteropancreatic endocrine tumors.

神经元中间丝的表达与胃肠胰腺内分泌肿瘤临床行为的关系。

基本信息

批准号：
20790281
负责人：
ISHIDA Mitsuaki
金额：
$ 0.83万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2009
项目状态：
已结题

项目摘要

Gastroenteropancreatic carcinoid tumors (well-differentiated endocrine tumors) are thought to be low-grade malignant tumor, and the parameters of the metastatic potential have not been completely established. Peripherin and α-internexin belong to the neuronal intermediate filament. In this research, I analyzed the relationship of the expression of peripherin and α-internexin and the clinical behavior of gastroenteropancreatic carcinoid tumors. Peripherin was diffusely expressed in the rectal carcinoid tumors without metastasis, but the expression of peripherin was decreased or absent in the rectal carcinoid tumors with metastasis. Approximately half cases of the rectal carcinoid tumors without metastasis showed positive immunoreactivity for α-internexin. In contrast, both of them were diffusely expressed in all of the appendiceal carcinoid tumors. These results suggested that the surveillance of loss of peripherin expression may be useful to predict the risk of metastasis in rectal carcinoid tumors, and the expression pattern of neuronal intermediate filaments depended on the site of origin of carcinoid tumors.

胃肠道胰腺类癌（分化良好的内分泌肿瘤）被认为是低度恶性肿瘤，其转移潜能的参数尚未完全确定。Peripherin和α-interexin属于神经元中间丝。本研究分析外周蛋白和α-internexin在胃肠胰腺类癌中的表达与其临床行为的关系。Peripherin在无转移的直肠类癌中呈弥漫性表达，而在有转移的直肠类癌中表达减弱或缺失。在无转移的直肠类癌中，约有一半呈α-interexin阳性。相反，两者在所有的阑尾类癌中均呈弥漫性表达。这些结果表明，外周蛋白表达的损失的监测可能是有用的，以预测在直肠类癌转移的风险，和神经元中间丝的表达模式依赖于类癌肿瘤的起源部位。