The role of c-KIT positive cancer cells in a drug resistance of the intestinal tumors

c-KIT阳性癌细胞在肠道肿瘤耐药中的作用

• 批准号: 20790303
• 负责人: KITAMURA Takanori
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790303/
• 关键词: 腫瘍・マウスモデル・大腸癌; c-KIT; 抗癌剤; 大腸癌

Apc/Smad4 compound mutant mice develop intestinal adenocarcinomas with marked tumor invasion. We demonstrated here that cancer cells at the invasion fronts expressed a progenitor cell marker c-KIT. Although 5-fluorouracil treatments retracted the invasive adenocarcinomas, the c-KIT positive cancer cells did not disappeared from the tumors in contrast to the c-KIT negative cells. These results suggest that the c-KIT positive cells are resistant to 5-fluorouracil treatments.

Apc/Smad 4复合突变小鼠发生肠腺癌，具有显著的肿瘤浸润。我们在这里证明，癌细胞在入侵前线表达祖细胞标志物c-KIT。尽管5-氟尿嘧啶治疗使浸润性腺癌消退，但与c-KIT阴性细胞相比，c-KIT阳性癌细胞并未从肿瘤中消失。这些结果表明c-KIT阳性细胞对5-氟尿嘧啶治疗具有抗性。

项目成果

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wne signaling.

smoothened 水平降低可通过下调 Wn​​e 信号传导来抑制肠道肿瘤发生。

• 发表时间: 2009
• 期刊: Gastroenterology 137(2)
• 作者: Arimura S;Matsunaga A;Kitamura T;Aoki K;Aoki M;Taketo MM.
• 通讯作者: Taketo MM.

腸癌の浸潤・転移における骨髄由来 CCR1発現細胞の役割

骨髓源性CCR1表达细胞在肠癌侵袭和转移中的作用

• 发表时间: 2009
• 作者: 北村剛規;藤下晃章;武藤誠
• 通讯作者: 武藤誠

The role of CCR1-expressing myeloid cells in invasion and metastasis of colon cancer cells

表达CCR1的骨髓细胞在结肠癌细胞侵袭和转移中的作用

• 发表时间: 2009
• 作者: Taketo;M.M.;武藤誠;武藤誠;北村剛規
• 通讯作者: 北村剛規

Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas

• DOI: 10.1038/labinvest.2008.107
• 发表时间: 2009-01-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Kitamura, Takanori;Biyajima, Kyoko;Taketo, Makoto M.
• 通讯作者: Taketo, Makoto M.

Inactivation of CCR1 suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

在小鼠模型中，CCR1 失活可通过阻止未成熟骨髓细胞的积累来抑制结肠癌肝转移。

• 期刊: Proc Natl Acad Sci USA (In press)
• 作者: Kitamura T;Fujishita T;Loetscherb P;Reveszb L;Hashidac H;Kizaka-Kondohd S;Aoki M;Taketo MM
• 通讯作者: Taketo MM