Cross-regulatory mechanisms of innate immunity and autophagy

自噬是一种在真核生物中保守的细胞内整体降解系统。在哺乳动物中，自噬具有多种生理作用，如饥饿反应、蛋白质质量控制、宿主防御等。然而，自噬调控的分子机制尚不清楚。在这里，我的研究重点是先天免疫和自噬的交叉调节机制。我发现，TAB2和TAB3，以前被认为是参与先天免疫的适配蛋白，在哺乳动物细胞中负调控基础自噬。

Autophagy is an intracellular bulk degradation system conserved among eukaryotes. In mammals, autophagy plays many physiological roles such as starvation response, protein quality control, host defense and so on. However, the molecular mechanisms of autophagy regulation are not well understood. Here, I focused my study on cross-regulatorymechanisms of innate immunity and autophagy. I found that TAB2 and TAB3, previously characterized as adapter proteins involved in innate immunity, negatively egulate basal autophagy in mammalian cells.